Huntington’s Disease

Written Reports (choice of B1 or B2:))  Study a genetic disease from the OMIM database. Work out the gene and mutation behind the disease, the mechanism and symptomology of the resulting syndrome, the availability and use of animal models, current treatments and potential for gene therapy.  ( in this case, we are writing about HUNTINGTON’S DISEASE) Guideline: ( must have the following) Title Authors and Affiliations Abstract Introduction Experimental Procedures Results and 5 images: explaining them(  and where in the pape Discussion Acknowledgements References Figure Legends Figures Write briefly in your own words the purpose of each of these parts.  questioon is ask why writing the paper: 1. if you wanna reports on an illiness that arises from a genetic mutation that inactivates an enzyme? 2. where in the metabolic pathway does that reaction hold? 3. what is the subtracte? what is the produect what is the structure of the enzyme ? what is the position of the common mutation inactivate the enzyme TERM PAPER RESEARCH: Back to References. When researching a term paper, use a good science library. Start with PubMed!. PubMed is an online database for biochemistry and molecular biology literature searching. PubMed can be accessed through the National Library of Medicine website at the National Center for Biotechnology Information (http:www.ncbi.nlm.nih.gov/). When the site opens up, click on PubMed. Then click on the colored rectangle (dialog box) and enter the key words or author (last name followed by initials, no punctuation) for your search. Then click on Search. After the search is done, you can click on the titles to see and print abstracts. Some full length papers are also available online (open access). You can click on Related Papers to see additional references. Internet access can be obtained at various places at York College; ask at the library or see your instructor. A variety of primary source journals should be consulted, including Nature, Science, Proceedings of the National Academy of Sciences, Molecular and Cellular Biology, Cell, Nucleic Acids Research, Journal of Molecular Biology and The Journal of Biological Chemistry. We have some of these journals in the York College library. Besides, York College subscribes to a literature service such as Science Direct, and additional papers that are not included in the online collection can be obtained electronically through Interlibrary Loan. Look through the shelf copy of each of these journals weekly and bring interesting topics and titles to class. The easiest way to research a term paper is to start with a recent primary source or review article (key paper) on your chosen topic. Then, turn to the reference section of the key paper every time you read an important bit of information with a text reference citation. Include these references in your notes and state what they are about. Follow up by collecting, reading and annotating the relevant references. You will have circumscribed a body of primary source information when you see the same references appearing over and over again. Then you should be ready to write your term paper based on your notes. Every paper needs a focus, which should emerge from your literature survey although you may not know what it is when you start. Focus also means that you should provide depth based on closely reading several solid research articles. Depth is more important than breadth. Avoid general topics like “prospects for gene therapy”; instead, zero in on a specific topic such as “Recent progress and prospects for treatment of Duchene’s Muscular Dystrophy by gene therapy”. The paper should be shaped like a funnel. Start with a broad summary and quickly bring the paper to a narrow focus. Google Scholar is another useful source for references. It has a user-friendly dialog window where you can type in key words, author names, etc. The articles come up with the number of times they’ve been cited since publication, and the papers that cited a key reference can be useful for updating a research topic. One of the most useful features is ‘Cite’, which allows you to copy the reference and paste it into your reference section. Use APA style. Referencing in a Term Paper. Your term paper needs text reference citations and a reference section. A text reference citation should appear every time you cite published non-textbook information. Don’t quote; paraphrase and reference! The format for a text reference citation is last name only (author, year), (author and author, year) or (author et al., year), depending on number of authors (one, two, three or more). One acceptable format for a reference in the reference section is: First author (last name, first initial), later authors (first initial, last name). Year. Title. Journal. Volume: First page – last page. You will encounter variations, but this one is both readable and informative. The title should be included because it tells you and other readers what the cited work is about. Headings in a term paper. Your term paper should be subdivided by a title, headings and subheadings, much like a journal article. But because it is a library research paper, not a laboratory research paper, the headings would not be Methods, Results and Discussion. Instead you should have an Abstract, Introduction and further headings determined by a natural division of the subject you are reviewing, determined by content.

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